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Article

Parkinson's Disease Patient-Specific Striatum Organoids Show Hallmarks of Increased Inflammation.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2026

Barmpa Kyriaki, Saraiva Claudia, Zagare Alise, Tuzza Mona, Longworth Joseph, Zuccoli Elisa, Hufnagel Katrin, Skwirblies Florian, Schmidt Ronny, Brenner Dirk, Schröder Christoph, Schwamborn Jens C

Abstract excerpt

BACKGROUND: Dopaminergic neurons from the substantia nigra pars compacta project their axons into the dorsal striatum, forming the nigrostriatal pathway. In Parkinson's disease (PD), dopaminergic terminals degenerate in the striatum, leading to dopamine depletion, which in turn causes alterations in the basal ganglia circuits that are essential for movement control. However, the reasons for dopaminergic neuron...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41670164
DOI: 10.1002/mds.70176
PMCID: PMC13067305

Genes

CDK5
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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