Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells.

The Journal of comparative neurology - 1 May 2020

Candelario Kate M, Balaj Leonora, Zheng Tong, Skog Johan, Scheffler Bjorn, Breakefield Xandra, Schüle Birgitt, Steindler Dennis A

Abstract excerpt

Extracellular vesicles, including exosomes/microvesicles (EMVs), have been described as sensitive biomarkers that represent disease states and response to therapies. In light of recent reports of disease-mirroring EMV molecular signatures, the present study profiled two EMVs from different Parkinson's disease (PD) tissue sources: (a) neural progenitor cells derived from an endogenous adult stem/progenitor cell,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Exosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Mutation

Share to Neural Stem Cells

Share to Parkinson Disease

Share to Transcriptome

Source

Identifiers

PMID: 31743443
DOI: 10.1002/cne.24819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells.PMID 31743443Read ↗

The Cellular and Extra-Cellular Proteomic Signature of Human Dopaminergic Neurons Carrying the LRRK2 G2019S MutationSemantic proximity Read ↗

Induced pluripotent stem cell‐based modeling of mutant LRRK 2‐associated Parkinson's diseaseSemantic proximity Read ↗

Cellular and Extracellular microRNA Dysregulation in LRRK2-Linked Parkinson’s DiseaseSemantic proximity Read ↗

The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson's disease.Semantic proximity Read ↗

The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s diseaseSemantic proximity Read ↗

Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells.Semantic proximity Read ↗

A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s DiseaseSemantic proximity Read ↗

Identification of distinct circulating exosomes in Parkinson's diseaseSemantic proximity Read ↗

Insights Into the Proteomic Profiling of Extracellular Vesicles for the Identification of Early Biomarkers of NeurodegenerationSemantic proximity Read ↗

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and FunctionalitySemantic proximity Read ↗

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's diseaseSemantic proximity Read ↗

Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.