Article

Molecular recording of cellular protein kinase activity with chemical labeling

2024-09-11

Abstract excerpt

Protein kinases control most cellular processes and aberrant kinase activity is involved in numerous diseases. To investigate the link between specific kinase activities and cellular phenotypes in heterogeneous cell populations and in vivo , we introduce molecular recorders of kinase activities for later analysis. Based on split-HaloTag and a phosphorylation-dependent molecular switch, our recorders become rapidl...

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Identifiers and source

Literature Corpus work: 54039801-c29c-5296-bb6a-f7fe3c6f5203
DOI: 10.1101/2024.09.11.611894

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