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Article

A conditional mutant of the fatty acid synthase unveils unexpected cross talks in mycobacterial lipid metabolism.

Open biology - 1 Feb 2017

Cabruja Matías, Mondino Sonia, Tsai Yi Ting, Lara Julia, Gramajo Hugo, Gago Gabriela

Abstract excerpt

Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex mycobacteria cell wall and in the storage lipids inside the cell. In order to study the role of the type I FAS system in Mycobacterium lipid metabolism in vivo, we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28228470
DOI: 10.1098/rsob.160277
PMCID: PMC5356441

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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