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The Molecular Genetics of Mycolic Acid Biosynthesis

15 Aug 2014

Abstract excerpt

Mycolic acids are major and specific long-chain fatty acids that represent essential components of the Mycobacterium tuberculosis cell envelope. They play a crucial role in the cell wall architecture and impermeability, hence the natural resistance of mycobacteria to most antibiotics, and represent key factors in mycobacterial virulence. Biosynthesis of mycolic acid precursors requires two types of fatty acid...

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PMID: 26104214
DOI: 10.1128/microbiolspec.mgm2-0003-2013

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