Article

FasR regulates fatty acid biosynthesis and is essential for virulence of <i>Mycobacterium tuberculosis</i>

2020-06-09

Abstract excerpt

Mycobacterium tuberculosis , the etiologic agent of human tuberculosis, is the world’s leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition of the cell envelope, which adapts to the variable host environment and defines the fate of infection by actively interacting with and modulating immune responses. However, while much has been...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16cb6ef9-9008-582c-b4d7-20430fd74c03
DOI: 10.1101/2020.06.08.140004

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FasR regulates fatty acid biosynthesis and is essential for virulence of <i>Mycobacterium tuberculosis</i>DOI 10.1101/2020.06.08.140004Read

Multiple deletions in the polyketide synthase gene repertoire of<i>Mycobacterium tuberculosis</i>reveal functional overlap of cell envelope lipids in host-pathogen interactionsSemantic proximity Read

Sphingomyelin is critical in organizing phosphoinositide dynamics during phagocytic uptake of <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Pathogen roid rage: Cholesterol utilization by<i>Mycobacterium tuberculosis</i>Semantic proximity Read

The Molecular Genetics of Mycolic Acid BiosynthesisSemantic proximity Read

Host and bacterial lipid metabolism during tuberculosis infections: possibilities to synergise host- and bacteria-directed therapiesSemantic proximity Read

Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesisSemantic proximity Read

Cell Envelope Lipids in the Pathophysiology of Mycobacterium TuberculosisSemantic proximity Read

Lipidomics and genomics of <i>Mycobacterium tuberculosis</i> reveal lineage‐specific trends in mycolic acid biosynthesisSemantic proximity Read

Intrabacterial lipid inclusions in mycobacteria: unexpected key players in survival and pathogenesis?Semantic proximity Read

Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities.Semantic proximity Read

Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.Semantic proximity Read

Recent advances in deciphering the contribution of Mycobacterium tuberculosis lipids to pathogenesisSemantic proximity Read