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Article

Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.

Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2007

Jain Madhulika, Petzold Christopher J, Schelle Michael W, Leavell Michael D, Mougous Joseph D, Bertozzi Carolyn R, Leary Julie A, Cox Jeffery S

Abstract excerpt

Mycobacterium tuberculosis synthesizes specific polyketide lipids that interact with the host and are required for virulence. Using a mass spectrometric approach to simultaneously monitor hundreds of lipids, we discovered that the size and abundance of two lipid virulence factors, phthiocerol dimycocerosate (PDIM) and sulfolipid-1 (SL-1), are controlled by the availability of a common precursor, methyl malonyl...

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Acyl Coenzyme A
Fatty Acids
Lipid Metabolism
Lipids
Molecular Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycobacterium tuberculosis

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PMID: 17360366
DOI: 10.1073/pnas.0610634104
PMCID: PMC1829275

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