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Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex.

Microbiology (Reading, England) - 1 Dec 2007

Brown Alistair K, Bhatt Apoorva, Singh Albel, Saparia Elesh, Evans Alex F, Besra Gurdyal S

Abstract excerpt

Mycolic acids are vital components of the Mycobacterium tuberculosis cell wall and are essential for survival. While most components of the fatty acid synthase-II (FAS-II) enzymic machinery that synthesizes these long chain alpha-alkyl, beta-hydroxy fatty acids have been identified, the gene encoding the beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase activity has remained elusive. Recent...

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PMID: 18048930
DOI: 10.1099/mic.0.2007/012419-0

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FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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