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Article

MmpL3 is the flippase for mycolic acids in mycobacteria

11 Jul 2017

Abstract excerpt

Significance Biological membranes define cellular boundaries, allow compartmentalization, and represent a prerequisite for life; yet, our understanding of membrane biogenesis remains rudimentary. Mycobacteria, including the human pathogen Mycobacterium tuberculosis , are surrounded by a double-membrane cell envelope that makes them intrinsically resistant to many antibiotics. Specifically, the outer membrane (OM)...

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PMID: 28698380
DOI: 10.1073/pnas.1700062114

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