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Article

Specificity of SNP detection with molecular beacons is improved by stem and loop separation with spacers.

The Analyst - 13 Mar 2017

Farzan Valentina M, Markelov Mikhail L, Skoblov Alexander Yu, Shipulin German A, Zatsepin Timofei S

Abstract excerpt

Molecular beacons (MBs) are valuable tools in molecular biology, clinical diagnostics and analytical chemistry. Here we describe a novel approach for the design of MBs with nucleotide or non-nucleotide linkers between the stem and loop regions. Such modified MBs have significantly improved specificity and performance for single nucleotide polymorphism (SNP) detection. These advantages are especially distinct,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28220155
DOI: 10.1039/c6an02441f

Genes

ADRB2
NOS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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