Article
Detection of SNP-containing human DNA sequences using a split sensor with a universal molecular beacon reporter.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Gerasimova Yulia V, Ballantyne Jack, Kolpashchikov Dmitry M
Abstract excerpt
Hybridization-based techniques have been extensively employed for the analysis of specific DNA/RNA sequences. Herein, we describe highly specific inexpensive smart hybridization-based sensor that takes advantage of a universal molecular beacon probe as a fluorescent reporter. The sensor has a straightforward design, and demonstrates improved selectivity and specificity of nucleic acid recognition. It is...
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