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Article

Dumbbell-shaped DNA analytes amplified by polymerase chain reaction for robust single-nucleotide polymorphism genotyping by affinity capillary electrophoresis.

Analytical chemistry - 4 Jun 2013

Shibata Hideaki, Ogawa Atsushi, Kanayama Naoki, Takarada Tohru, Maeda Mizuo

Abstract excerpt

A sample preparation method was developed for single-nucleotide polymorphism (SNP) genotyping based on hybridization between a single-stranded DNA (ssDNA) analyte and an allele-specific oligonucleotide (ASO) probe. When the SNP site is located in the stable secondary structure, the folding of this analyte imposes kinetic penalties on the hybridization with the ASO probe. To address this issue, the sequence of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23659631
DOI: 10.1021/ac400900b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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