Article
Label-free molecular beacon system based on DNAs containing abasic sites and fluorescent ligands that bind abasic sites.
Chemistry (Weinheim an der Bergstrasse, Germany) - 4 Oct 2011
Sato Yusuke, Nishizawa Seiichi, Teramae Norio
Abstract excerpt
A new class of label-free molecular beacon (MB) system based on DNA strands that contain abasic (AP) sites (AP-DNA) and adopt stem-loop structures, in combination with fluorescent ligands that bind these AP sites, has been developed. Unlike a conventional MB, which requires covalent labeling of the MB with a fluorophore and a quencher, the developed system (APMB) does not require covalent attachment of signal...
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