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Article

Terminal protection of small molecule-linked DNA: A versatile biosensor platform for protein binding and gene typing assay.

Analytical chemistry - 15 Apr 2011

Wu Zhan, Wang Hongqi, Guo Min, Tang Li-Juan, Yu Ru-Qin, Jiang Jian-Hui

Abstract excerpt

Assays of small molecule-protein interactions are of tremendous importance in chemical genetics, molecular diagnostics, and drug development. This work reports a new finding of generalized terminal protection that small molecule-DNA chimeras are protected from degradation by various DNA exonucleases, when the small molecule moieties are bound to their protein targets. This generalization converts small...

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PMID: 21438529
DOI: 10.1021/ac1033769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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