Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic risk scores in familial Alzheimer disease.

Neurology - 21 Mar 2017

Tosto Giuseppe, Bird Thomas D, Tsuang Debby, Bennett David A, Boeve Bradley F, Cruchaga Carlos, Faber Kelley, Foroud Tatiana M, Farlow Martin, Goate Alison M, Bertlesen Sarah, Graff-Radford Neill R, Medrano Martin, Lantigua Rafael, Manly Jennifer, Ottman Ruth, Rosenberg Roger, Schaid Daniel J, Schupf Nicole, Stern Yaakov, Sweet Robert A, Mayeux Richard

Abstract excerpt

OBJECTIVE: To investigate the association between a genetic risk score (GRS) and familial late-onset Alzheimer disease (LOAD) and its predictive value in families multiply affected by the disease. METHODS: Using data from the National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease (National Institute on Aging-Late-Onset Alzheimer's Disease Family Study), mixed regression models tested the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caribbean Region

Share to Family Health

Share to Hispanic or Latino

Share to Logistic Models

Share to Multifactorial Inheritance

Share to ROC Curve

Source

Open in PubMed Open full text

Identifiers

PMID: 28213371
DOI: 10.1212/WNL.0000000000003734
PMCID: PMC5373783

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk scores in familial Alzheimer disease.PMID 28213371Read ↗

Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics.Semantic proximity Read ↗

Epistatic Features and Machine Learning Improve Alzheimer's Disease Risk Prediction Over Polygenic Risk Scores.Semantic proximity Read ↗

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture.Semantic proximity Read ↗

Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity.Semantic proximity Read ↗

Polygenic Risk Score Reveals Genetic Heterogeneity of Alzheimer's Disease between the Chinese and European Populations.Semantic proximity Read ↗

Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.Semantic proximity Read ↗

Epistatic Features and Machine Learning Improve Alzheimer’s Risk Prediction Over Polygenic Risk ScoresSemantic proximity Read ↗

Association of whole-person eigen-polygenic risk scores with Alzheimer's disease.Semantic proximity Read ↗

Polygenic Risk Score of Sporadic late Onset Alzheimer Disease Reveals a Shared Architecture with the Familial and Early Onset FormsSemantic proximity Read ↗

Utility of Polygenic Risk Scores in Families with Exceptional LongevitySemantic proximity Read ↗

Polygenic Risk Scores for Alzheimer’s Disease and Mild Cognitive Impairment in Hispanics/Latinos in the U.S: The Study of Latinos – Investigation of Neurocognitive AgingSemantic proximity Read ↗

A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.