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Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics.

Annals of neurology - 1 Sept 2021

Sariya Sanjeev, Felsky Daniel, Reyes-Dumeyer Dolly, Lali Ricky, Lantigua Rafael A, Vardarajan Badri, Jiménez-Velázquez Ivonne Z, Haines Jonathan L, Shellenberg Gerard D, Pericak-Vance Margaret A, Paré Guillaume, Mayeux Richard, Tosto Giuseppe

Abstract excerpt

OBJECTIVE: Polygenic risk scores (PRSs) assess the individual genetic propensity to a condition by combining sparse information scattered across genetic loci, often displaying small effect sizes. Most PRSs are constructed in European-ancestry populations, limiting their use in other ethnicities. Here we constructed and validated a PRS for late-onset Alzheimer's Disease (LOAD) in Caribbean Hispanics (CH). METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34038570
DOI: 10.1002/ana.26131
PMCID: PMC8435026

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