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Article

Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE ε4.

The American journal of pathology - 1 Apr 2017

Postupna Nadia, Latimer Caitlin S, Larson Eric B, Sherfield Emily, Paladin Julie, Shively Carol A, Jorgensen Matthew J, Andrews Rachel N, Kaplan Jay R, Crane Paul K, Montine Kathleen S, Craft Suzanne, Keene C Dirk, Montine Thomas J

Abstract excerpt

Cognitive impairment in older individuals is a complex trait that in population-based studies most commonly derives from an individually varying mixture of Alzheimer disease, Lewy body disease, and vascular brain injury. We investigated the molecular composition of synaptic particles from three sources: consecutive rapid autopsy brains from the Adult Changes in Thought Study, a population-based cohort; four aged...

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Source

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Identifiers

PMID: 28212814
DOI: 10.1016/j.ajpath.2016.12.010
PMCID: PMC5397713

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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