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Article

Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways.

Addiction (Abingdon, England) - 1 Jun 2026

Trofimova Olga, Iuliani Ilaria, Bergmann Sven

Abstract excerpt

BACKGROUND AND AIMS: Tobacco smoking is a major risk factor for cardiovascular and lung diseases. A better understanding of its neurobiological underpinnings will benefit the prevention of smoking-related illnesses and mortality. Previous studies link smoking to increased iron concentration in the striatum, a central component of the brain's reward system, and to reduced cognitive performance. This study aimed to...

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Identifiers

PMID: 41619226
DOI: 10.1111/add.70311
PMCID: PMC13155275

Genes

DLX5
DRD2
GGACT
ING5
NAT16
NCAM1
NLRP7
PLEKHM1
SEMA6D
TENM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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