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Correlative Ultrastructural Mapping of Lewy Pathology Reveals Regional Diversity in Parkinson’s and Dementia with Lewy bodies

2025-12-22

Abstract excerpt

Lewy body diseases, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), are defined by neuronal accumulation of misfolded α-synuclein (α-Syn), yet the ultrastructural diversity of these inclusions across brain regions and disease contexts remains unclear. Here, we applied large-scale correlative light and electron microscopy (CLEM) to map α-Syn pathology across cortical regions (entorhinal cort...

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Literature Corpus work
9762e1ac-8134-567a-95ce-1e00226de842
DOI
10.64898/2025.12.19.695426
Open publication

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