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Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6. Htt Q111/+ model of Huntington’s disease

2016-10-14

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We investigated the appearance and progression of disease-relevant signs in the B6. Htt Q111/+ mouse, a genetically precise model of the mutation that causes Huntington’s disease (HD). We find that B6. Htt Q111/+ mice are healthy, show no overt signs of central or peripheral inflammation, and no gross motor impairment as late as 12 months of age. Behaviorally, we find that 4-9 month old B6. Htt Q111/+ mice have...

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Literature Corpus work: 2976978d-9050-5308-8a11-0d8457312d21
DOI: 10.1101/081109

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Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6. <i>Htt</i> <sup> <i>Q111/+</i> </sup> model of Huntington’s disease

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