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Article

Deep clinical and neuropathological phenotyping of Pick disease.

Annals of neurology - 1 Feb 2016

Irwin David J, Brettschneider Johannes, McMillan Corey T, Cooper Felicia, Olm Christopher, Arnold Steven E, Van Deerlin Vivianna M, Seeley William W, Miller Bruce L, Lee Edward B, Lee Virginia M-Y, Grossman Murray, Trojanowski John Q

Abstract excerpt

OBJECTIVE: To characterize sequential patterns of regional neuropathology and clinical symptoms in a well-characterized cohort of 21 patients with autopsy-confirmed Pick disease. METHODS: Detailed neuropathological examination using 70μm and traditional 6μm sections was performed using thioflavin-S staining and immunohistochemistry for phosphorylated tau, 3R and 4R tau isoforms, ubiquitin, and C-terminally...

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Identifiers

PMID: 26583316
DOI: 10.1002/ana.24559
PMCID: PMC4755803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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