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Article

Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate.

Clinical pharmacology and therapeutics - 1 Apr 2004

McConnachie Lisa, Bodor Miklos, Kowdley Kris, Levy Adam, Tung Bruce, Thummel Kenneth, Phillips Brian, Bajpai Manoj, Chi Victor, Esmay Joel D, Shen Danny D, Ho Rodney J Y

Abstract excerpt

OBJECTIVE: The goal of this study was to develop and validate a cytochrome P450 (CYP) 2D6 probe substrate with improved sensitivity to elucidate the relationship of CYP2D6 ribonucleic acid transcript levels, genotype, and enzyme activity in human liver biopsy samples. METHODS: CYP2D6 activity in tissue homogenates of liver biopsy specimens collected from control subjects (with no apparent liver disease), liver...

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PMID: 15060507
DOI: 10.1016/j.clpt.2003.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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