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Article

RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2010

Fang Fang, Lue Lih-Fen, Yan Shiqiang, Xu Hongwei, Luddy John S, Chen Doris, Walker Douglas G, Stern David M, Yan Shifang, Schmidt Ann Marie, Chen John X, Yan Shirley ShiDu

Abstract excerpt

Microglia are critical for amyloid-beta peptide (Abeta)-mediated neuronal perturbation relevant to Alzheimer's disease (AD) pathogenesis. We demonstrate that overexpression of receptor for advanced glycation end products (RAGE) in imbroglio exaggerates neuroinflammation, as evidenced by increased...

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Identifiers

PMID: 19906677
DOI: 10.1096/fj.09-139634
PMCID: PMC3231946

Genes

APP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19906677-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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