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Article

Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors.

Cell reports - 14 Feb 2017

Boulianne Bryant, Robinson Mark E, May Philippa C, Castellano Leandro, Blighe Kevin, Thomas Jennifer, Reid Alistair, Müschen Markus, Apperley Jane F, Stebbing Justin, Feldhahn Niklas

Abstract excerpt

In human leukemia, lineage-specific genes represent predominant targets of deletion, with lymphoid-specific genes frequently affected in lymphoid leukemia and myeloid-specific genes in myeloid leukemia. To investigate the basis of lineage-specific alterations, we analyzed global DNA damage in primary B cell precursors expressing leukemia-inducing oncogenes by ChIP-seq. We identified more than 1,000 sensitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28199841
DOI: 10.1016/j.celrep.2017.01.057
PMCID: PMC5318656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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