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Article

Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma.

Cancer discovery - 1 Oct 2015

Ryan Russell J H, Drier Yotam, Whitton Holly, Cotton M Joel, Kaur Jasleen, Issner Robbyn, Gillespie Shawn, Epstein Charles B, Nardi Valentina, Sohani Aliyah R, Hochberg Ephraim P, Bernstein Bradley E

Abstract excerpt

UNLABELLED: B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel approach called "pinpointing enhancer-associated rearrangements by chromatin immunoprecipitation," or PEAR-ChIP, to simultaneously map enhancer activity and proximal rearrangements in lymphoma cell lines and patient biopsies. This method detects...

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Topics

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Share to Chromatin Immunoprecipitation
Share to Chromosomes, Human, Pair 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, myc

Share to Lymphoma, B-Cell

Share to Lymphoma, Mantle-Cell

Share to MEF2 Transcription Factors

Share to p300-CBP Transcription Factors

Share to Proto-Oncogene Proteins c-bcl-6

Source

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Identifiers

PMID: 26229090
DOI: 10.1158/2159-8290.CD-15-0370
PMCID: PMC4592453

Genes

MYC
BCL6
BCL2
CCND1
CIITA
NOTCH1
SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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