Article

Molecular analysis of leukaemia genomes during malignant transformation and leukaemia progression

2018-01-01

Abstract excerpt

This thesis details a tripartite approach to understanding genetic and epigenetic modifications in human leukaemia. First, an in vitro mouse model of precursor B-cell leukaemia was established by retroviral transduction of primary B-cell precursors with the oncogenes BCR-ABL1 or MYC. The model was used to study DNA damage incurred during the initial phase of oncogene activation i.e. oncogenic stress. Analysis of γ...

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Literature Corpus work: 4847afa4-b901-5bf9-9725-e040f59a2eca
DOI: 10.25560/79664

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