Article
The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression.
Nature communications - 14 Feb 2017
Liu Ning Qing, Ter Huurne Menno, Nguyen Luan N, Peng Tianran, Wang Shuang-Yin, Studd James B, Joshi Onkar, Ongen Halit, Bramsen Jesper B, Yan Jian, Andersen Claus L, Taipale Jussi, Dermitzakis Emmanouil T, Houlston Richard S, Hubner Nina C, Stunnenberg Hendrik G
Abstract excerpt
Genome-wide association studies have identified a great number of non-coding risk variants for colorectal cancer (CRC). To date, the majority of these variants have not been functionally studied. Identification of allele-specific transcription factor (TF) binding is of great importance to understand regulatory consequences of such variants. A recently developed proteome-wide analysis of disease-associated SNPs...
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