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Article

Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1.

Human molecular genetics - 15 Apr 2014

Biancolella Michela, Fortini Barbara K, Tring Stephanie, Plummer Sarah J, Mendoza-Fandino Gustavo A, Hartiala Jaana, Hitchler Michael J, Yan Chunli, Schumacher Fredrick R, Conti David V, Edlund Christopher K, Noushmehr Houtan, Coetzee Simon G, Bresalier Robert S, Ahnen Dennis J, Barry Elizabeth L, Berman Benjamin P, Rice Judd C, Coetzee Gerhard A, Casey Graham

Abstract excerpt

Genome-wide association studies of colorectal cancer (CRC) have identified a number of common variants associated with modest risk, including rs3802842 at chromosome 11q23.1. Several genes map to this region but rs3802842 does not map to any known transcribed or regulatory sequences. We reasoned, therefore, that rs3802842 is not the functional single-nucleotide polymorphism (SNP), but is in linkage disequilibrium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Chromatin Immunoprecipitation
Chromosomes, Human, Pair 11
Colorectal Neoplasms
Electrophoretic Mobility Shift Assay
Enhancer Elements, Genetic
Luciferases
Quantitative Trait Loci
Tumor Cells, Cultured

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Identifiers

PMID: 24256810
DOI: 10.1093/hmg/ddt584
PMCID: PMC3959808

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