Article
A Rare Missense Variant in TCF7L2 Associates with Colorectal Cancer Risk by Interacting with a GWAS-Identified Regulatory Variant in the MYC Enhancer.
Cancer research - 1 Sept 2018
Chang Jiang, Tian Jianbo, Yang Yang, Zhong Rong, Li Jiaoyuan, Zhai Kan, Ke Juntao, Lou Jiao, Chen Wei, Zhu Beibei, Shen Na, Zhang Yi, Gong Yajie, Zhu Ying, Zou Danyi, Peng Xiating, Huang Kun, Miao Xiaoping
Abstract excerpt
Genome-wide association studies (GWAS) of colorectal cancer have identified several common susceptible variants in gene regulatory regions. However, low-frequency or rare coding risk variants have not been systematically investigated in patients with colorectal cancer from Chinese populations. In this study, we performed an exome-wide association analysis with 1,062 patients with colorectal cancer and 2,184...
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