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Article

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.

Nature genetics - 1 Aug 2009

Pomerantz Mark M, Ahmadiyeh Nasim, Jia Li, Herman Paula, Verzi Michael P, Doddapaneni Harshavardhan, Beckwith Christine A, Chan Jennifer A, Hills Adam, Davis Matt, Yao Keluo, Kehoe Sarah M, Lenz Heinz-Josef, Haiman Christopher A, Yan Chunli, Henderson Brian E, Frenkel Baruch, Barretina Jordi, Bass Adam, Tabernero Josep, Baselga José, Regan Meredith M, Manak J Robert, Shivdasani Ramesh, Coetzee Gerhard A, Freedman Matthew L

Abstract excerpt

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC proto-oncogene. These data provide strong support for a biological...

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Topics

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Share to Cell Line, Tumor
Share to Chromosomes, Human, Pair 8
Share to Colorectal Neoplasms
Share to Enhancer Elements, Genetic
Share to Proto-Oncogene Mas
Share to Proto-Oncogene Proteins c-myc
Share to TCF Transcription Factors
Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 19561607
DOI: 10.1038/ng.403
PMCID: PMC2763485

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.PMID 19561607Read ↗

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.Semantic proximity Read ↗

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