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Article

A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90.

Oncogene - 1 Feb 2020

Yu Chen-Yang, Han Ji-Xuan, Zhang Junfang, Jiang Penglei, Shen Chaoqin, Guo Fangfang, Tang Jiayin, Yan Tingting, Tian Xianglong, Zhu Xiaoqiang, Ma Dan, Hu Ye, Xie Yuanhong, Du Wan, Zhong Ming, Chen Jinxian, Liu Qiang, Sun Danfeng, Chen Yingxuan, Zou Weiping, Hong Jie, Chen Haoyan, Fang Jing-Yuan

Abstract excerpt

Genome-wide association studies (GWASs) implicate 16q22.1 locus in risk for colorectal cancer (CRC). However, the underlying oncogenic mechanisms remain unknown. Here, through comprehensive filtration, we prioritized rs7198799, a common SNP in the second intron of the CDH1, as the putative causal variant. In addition, we found an association of CRC-risk allele C of rs7198799 with elevated transcript level of...

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PMID: 31641208
DOI: 10.1038/s41388-019-1055-4
PMCID: PMC7002302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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