Article
Colorectal cancer risk variant rs7017386 modulates two oncogenic lncRNAs expression via ATF1-mediated long-range chromatin loop.
Cancer letters - 10 Oct 2021
Wang Haoxue, Zhu Ying, Chen Hongda, Yang Nan, Wang Xiaoyang, Li Bin, Ying Pingting, He Heng, Cai Yimin, Zhang Ming, Niu Siyuan, Li Yue, Lu Zequn, Peng Xiating, Zou Danyi, Zhong Rong, Chang Jiang, Dai Min, Tian Jianbo, Miao Xiaoping
Abstract excerpt
The activating transcription factor 1 (ATF1) has been identified as a vital pathogenic factor in the progression of colorectal cancer (CRC), whiles, the precise regulatory mechanisms remain elusive. Here, we comprehensively characterized the ATF1 cistrome by RNA-seq and ChIP-seq assays in CRC cell lines. As the results, we identified 358 genes differentially regulated and 15,029 ATF1 binding sites and...
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