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Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis

14 Apr 2022

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. The role of the developmental transcription factor Sine oculis homeobox homolog 1 (SIX1) in the pathophysiology of lung fibrosis is not known. IPF lung tissue samples and IPF-derived alveolar type II cells (AT2) showed a significant increase in SIX1 mRNA and protein levels, and the SIX1 transcriptional coactivators EYA1 and...

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PMID: 35420997
DOI: 10.1172/jci.insight.142984

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