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Article

Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice.

American journal of respiratory and critical care medicine - 15 Aug 2009

Mitani Akihisa, Nagase Takahide, Fukuchi Kazunori, Aburatani Hiroyuki, Makita Ryosuke, Kurihara Hiroki

Abstract excerpt

RATIONALE: Transcriptional coactivator with PDZ-binding motif (TAZ) is assumed to act as a coactivator of several transcription factors including smad2/3. In the lung, surfactant protein C (Sftpc) is known to be a downstream target of thyroid transcription factor-1 (TTF-1)-TAZ transcriptional coactivation. OBJECTIVES: The lung phenotype of Taz-deficient mice was explored. METHODS: Taz-deficient mice were analyzed...

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Source

Identifiers

PMID: 19498055
DOI: 10.1164/rccm.200812-1827OC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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