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Article

ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation.

The Journal of cell biology - 3 May 2021

Jones Dakota L, Meridew Jeffrey A, Link Patrick A, Ducharme Merrick T, Lydon Katherine L, Choi Kyoung M, Caporarello Nunzia, Tan Qi, Diaz Espinosa Ana Maria, Xiong Yuning, Lee Jeong-Heon, Ye Zhenqing, Yan Huihuang, Ordog Tamas, Ligresti Giovanni, Varelas Xaralabos, Tschumperlin Daniel J

Abstract excerpt

Matrix stiffness is a central regulator of fibroblast function. However, the transcriptional mechanisms linking matrix stiffness to changes in fibroblast phenotype are incompletely understood. Here, we evaluated the effect of matrix stiffness on genome-wide chromatin accessibility in freshly isolated lung fibroblasts using ATAC-seq. We found higher matrix stiffness profoundly increased global chromatin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33625469
DOI: 10.1083/jcb.202007152
PMCID: PMC7918622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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