Article

Cartilage intermediate layer protein attenuates bleomycin-induced pulmonary fibrosis through the TGF-β1/Smad3 negative feedback loop

2022-08-04

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF), a chronic, progressive interstitial lung disease, has multiple etiologies. It is characterized by excess myofibrocyte aggregation and extracellular matrix deposition. However, its pathomechanisms have not been conclusively elucidated. We performed a comprehensive study of mRNAs in human pulmonary fibrosis using GSE10667 microarray data from the Gene Expression Omnibus (GEO) dat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1036e009-a04b-5418-b577-09fd2e059f51
DOI: 10.21203/rs.3.rs-1889746/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cartilage intermediate layer protein attenuates bleomycin-induced pulmonary fibrosis through the TGF-β1/Smad3 negative feedback loopDOI 10.21203/rs.3.rs-1889746/v1Read

Revisiting the role of MicroRNAs in the pathogenesis of idiopathic pulmonary fibrosisSemantic proximity Read

LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activationSemantic proximity Read

Role of MicroRNAs in Signaling Pathways Associated with the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Focus on Epithelial-Mesenchymal TransitionSemantic proximity Read

Klotho antagonizes pulmonary fibrosis through suppressing pulmonary fibroblasts activation, migration, and extracellular matrix production: a therapeutic implication for idiopathic pulmonary fibrosisSemantic proximity Read

Exploring key genes and mechanisms associated with idiopathic pulmonary fibrosis and lung adenocarcinomaSemantic proximity Read

Integration of Transcriptomic and Proteomic Profiles Identifies Potential Biomarkers in Idiopathic Pulmonary FibrosisSemantic proximity Read

Inhibition of lncRNA PFRL prevents pulmonary fibrosis by disrupting the miR-26a/smad2 loopSemantic proximity Read

Translational Regulators in Pulmonary Fibrosis: MicroRNAs, Long Non-Coding RNAs, and Transcript ModificationsSemantic proximity Read

Bioinformatic Analyses of Potential Key Genes in the Pathogenesis of Idiopathic Pulmonary FibrosisSemantic proximity Read

The Antifibrotic Effects and Mechanisms of MicroRNA-26a Action in Idiopathic Pulmonary FibrosisSemantic proximity Read

Latent transforming growth factor binding protein-2 (LTBP2), an IPF biomarker of clinical decline, promotes TGF-beta signaling and lung fibrosis in miceSemantic proximity Read

MicroRNAs as potential targets for progressive pulmonary fibrosisSemantic proximity Read