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Article

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis

19 Nov 2020

Abstract excerpt

INTRODUCTION: Fibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fibrosis (IPF) and comprise activated fibroblasts and myofibroblasts, the key effector cells responsible for dysregulated extracellular matrix deposition in multiple fibrotic conditions. The aim of this study was to define the major transcriptional programmes involved in fibrogenesis in IPF by profiling unmanipulated...

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PMID: 33214245
DOI: 10.1136/thoraxjnl-2020-214902

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