Article
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Molecular microbiology - 1 Oct 2006
Bray Patrick G, Mungthin Mathirut, Hastings Ian M, Biagini Giancarlo A, Saidu Dauda K, Lakshmanan Viswanathan, Johnson David J, Hughes Ruth H, Stocks Paul A, O'Neill Paul M, Fidock David A, Warhurst David C, Ward Stephen A
Abstract excerpt
It is accepted that resistance of Plasmodium falciparum to chloroquine (CQ) is caused primarily by mutations in the pfcrt gene. However, a consensus has not yet been reached on the mechanism by which resistance is achieved. CQ-resistant (CQR) parasite lines accumulate less CQ than do CQ-sensitive (CQS) parasites. The CQR phenotype is complex with a component of reduced energy-dependent CQ uptake and an additional...
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