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Article

ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish.

Journal of genetics and genomics = Yi chuan xue bao - 1 Sept 2024

Wang Pengcheng, Shi Wenxiang, Liu Sijie, Shi Yunjing, Jiang Xuechao, Li Fen, Chen Sun, Sun Kun, Xu Rang

Abstract excerpt

Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development. Defects in the process can result in severe organ mispositioning. Coiled-coil domain containing 141 (CCDC141) has been previously known as a centrosome-related gene, but its role in left-right (LR) asymmetry has not been characterized. In this study, we utilize the zebrafish model and human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39047937
DOI: 10.1016/j.jgg.2024.07.014

Genes

CCDC141
HDAC6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish.PMID 39047937Read ↗

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