Article
Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases.
Cell reports - 22 Sept 2020
Canesin Giacomo, Di Ruscio Annalisa, Li Mailin, Ummarino Simone, Hedblom Andreas, Choudhury Reeham, Krzyzanowska Agnieszka, Csizmadia Eva, Palominos Macarena, Stiehm Anna, Ebralidze Alexander, Chen Shao-Yong, Bassal Mahmoud A, Zhao Ping, Tolosano Emanuela, Hurley Laurence, Bjartell Anders, Tenen Daniel G, Wegiel Barbara
Abstract excerpt
Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of tumor stroma-expressed Hx in suppressing cancer progression. Labile heme and Hx levels are inversely correlated in the plasma of patients with prostate cancer (PCa). Further, low expression of Hx in PCa biopsies characterizes poorly differentiated tumors and correlates with earlier time to relapse. Significantly, heme...
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