Article

Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies

2021-12-10

Abstract excerpt

Tumor heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to therapy has remained challenging. Here we utilize clonal transcriptomics with WILD-seq; W holistic I nterrogation of L ineage D ynamics by seq uencing, in mouse models of triple-negative...

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Literature Corpus work: a319f5bf-73a1-52ad-818e-de55e0ab2e57
DOI: 10.1101/2021.12.09.471927

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