Increased expression of a set of genes enriched in oxygen binding function discloses a predisposition of breast cancer bone metastases to generate metastasis spread in multiple organs.

doi:10.1002/jbmr.1686

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Increased expression of a set of genes enriched in oxygen binding function discloses a predisposition of breast cancer bone metastases to generate metastasis spread in multiple organs.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2012

Capulli Mattia, Angelucci Adriano, Driouch Keltouma, Garcia Teresa, Clement-Lacroix Philippe, Martella Francesco, Ventura Luca, Bologna Mauro, Flamini Stefano, Moreschini Oreste, Lidereau Rosette, Ricevuto Enrico, Muraca Maurizio, Teti Anna, Rucci Nadia

Abstract excerpt

Bone is the preferential site of distant metastasis in breast carcinoma (BrCa). Patients with metastasis restricted to bone (BO) usually show a longer overall survival compared to patients who rapidly develop multiple metastases also involving liver and lung. Hence, molecular predisposition to generate bone and visceral metastases (BV) represents a clear indication of poor clinical outcome. We performed...

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PMID: 22714395
DOI: 10.1002/jbmr.1686

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