Article

The HES1-SOD1 Antagonism Shapes Senescence Heterogeneity and Impacts Metastatic Relapse of Circulating Tumor Cells

2026-08-20

Abstract excerpt

<h4>ABSTRACT</h4> Circulating tumor cells (CTCs) encounter multiple challenges within the blood microenvironment, including oxidative stress, flow shear forces, and immune surveillance, often leading to anoikis. Recently, a transitional state of CTC senescence has been identified, contributing to metastatic inefficiency. However, the molecular mechanisms linking senescent CTCs to disease relapse remain to be defi...

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Literature Corpus work: 00484b59-3b5b-5549-b2ef-5235315d6bd8
DOI: 10.64898/2026.08.19.745859

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