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An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression

16 Dec 2021

Abstract excerpt

Blood-borne metastasis of breast cancer involves a series of tightly regulated sequential steps, including the growth of a primary tumor lesion, intravasation of circulating tumor cells (CTC), and adaptation in various distant metastatic sites. The genes orchestrating each of these steps are poorly understood in physiologically relevant contexts, owing to the rarity of experimental models that faithfully...

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PMID: 34916221
DOI: 10.1158/0008-5472.can-21-3908

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