Article
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation.
Frontiers of medicine - 1 Oct 2024
Chen Shubei, Liu Dianjia, Chen Bingyi, Li Zijuan, Chang Binhe, Xu Chunhui, Li Ningzhe, Feng Changzhou, Hu Xibo, Wang Weiying, Zhang Yuanliang, Xie Yinyin, Huang Qiuhua, Wang Yingcai, Nimer Stephen D, Chen Saijuan, Chen Zhu, Wang Lan, Sun Xiaojian
Abstract excerpt
SETD2 is the only enzyme responsible for transcription-coupled histone H3 lysine 36 trimethylation (H3K36me3). Mutations in SETD2 cause human diseases including cancer and developmental defects. In mice, Setd2 is essential for embryonic vascular remodeling. Given that many epigenetic modifiers have recently been found to possess noncatalytic functions, it is unknown whether the major function(s) of Setd2 is...
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