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Article

Comprehensive molecular characterization of human colon and rectal cancer.

Nature - 18 Jul 2012

Abstract excerpt

To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and messenger RNA and microRNA expression. A subset of these samples (97) underwent low-depth-of-coverage whole-genome sequencing. In total, 16% of colorectal carcinomas were found to be hypermutated: three-quarters of these had the...

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Topics

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Share to Colonic Neoplasms
Share to DNA Copy Number Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutation Rate

Share to Rectal Neoplasms

Share to Sequence Analysis, DNA

Source

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Identifiers

PMID: 22810696
DOI: 10.1038/nature11252
PMCID: PMC3401966

Genes

APC
ARID1A
ERBB2
IGF2
KRAS
MLH1
MYC
NAV2
PIK3CA
POLE
SMAD4
SOX9
TCF7L1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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