Article

Effect of β-Arrestin 2 Downregulation on Morphine-Induced Antinociceptive Tolerance in Rodents: A Systematic Review and Meta-Analysis

2026-05-27

Abstract excerpt

<title>Abstract</title> <p>Background Morphine-induced antinociceptive tolerance severely limits the long-term clinical utility of opioid analgesics. β-arrestin 2 (βarr2), a G-protein-coupled receptor regulatory protein, has been proposed as a key mediator of µ-opioid receptor (MOR) desensitization and the consequent development of analgesic tolerance. Multiple preclinical studies employing diverse molecular str...

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Literature Corpus work: bd75d1f2-3259-5592-b357-a771201768af
DOI: 10.21203/rs.3.rs-9826868/v1

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