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Article

Computer prediction of paratope on antithrombotic antibody 10B12 and epitope on platelet glycoprotein VI via molecular dynamics simulation.

Biomedical engineering online - 28 Dec 2016

Liu Wenping, Liu Guangjian, Zhou Huiyun, Fang Xiang, Fang Ying, Wu Jianhua

Abstract excerpt

BACKGROUND: Interaction between immunoglobulin-like receptor glycoprotein VI (GPVI) and collagen plays a central role in platelet activation and sequent firm adhesion. Of various antithrombotic agents targeting GPVI, antibody 10B12 is of great potential to block the GPVI-collagen interaction, but less is known about 10B12 paratope and GPVI epitope. METHODS: Along the pathway in the computer strategy presented in...

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Identifiers

PMID: 28155721
DOI: 10.1186/s12938-016-0272-0
PMCID: PMC5260068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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