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Article

A strategy of designing the ligand of antibody affinity chromatography based on molecular dynamics simulation.

Journal of chromatography. A - 9 Sept 2016

Dai Lu, Li Weikang, Sun Fei, Li Baizhi, Li Hongrui, Zhang Hongxing, Zheng Qingchuan, Liang Chongyang

Abstract excerpt

Designing affinity ligands has always been the development focus of affinity chromatography. Previous antibody affinity ligand designs were mostly based on the crystal structure of protein A (UniProt code number: P38507), and the antibody-binding domains were modified according to the properties of amino acid residues. Currently, more effective bioinformatic prediction and experimental validation has been used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27524303
DOI: 10.1016/j.chroma.2016.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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