Back to search

Article

The enigmatic αIIb β-propeller: Structural insights from select missense mutations

2024-06-07

Abstract excerpt

<title>Abstract</title> <p>Integrin αIIbβ3 is the predominant receptor for fibrinogen which mediates platelet aggregation, an important step in hemostasis and thrombosis. Several mutations have been reported in the genes encoding αIIb and β3 subunits among patients with Glanzmann thrombasthenia, of which 177 are in the β-propeller domain. The two subunits form a heterodimer at the interface between β-propeller an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b0f034f7-a7b0-5401-a775-15b7b5cd8b06
DOI
10.21203/rs.3.rs-4453539/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The enigmatic αIIb β-propeller: Structural insights from select missense mutationsDOI 10.21203/rs.3.rs-4453539/v1
Molecular dynamics simulations involving different β-propeller mutations reported in Swiss and French patients correlate with their disease phenotypes.Semantic proximity
An αIIb mutation in patients with Glanzmann thrombasthenia located in the N-terminus of blade 1 of the β-propeller (Asn2Asp) disrupts a calcium binding site in blade 6.Semantic proximity
In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia.Semantic proximity
In silico analysis of Glanzmann variants of Calf-1 domain of αIIbβ3 integrin revealed dynamic allosteric effect.Semantic proximity
Molecular dynamics simulations corroborate recombinant expression studies carried out on three αIIb β-propeller mutations reported in Indian Glanzmann thrombasthenia patients.Semantic proximity
αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia.Semantic proximity
Glanzmann thrombasthenia: state of the art and future directions.Semantic proximity
A naturally occurring mutation near the C terminus of the beta-propeller of alpha(IIb) impair the transport of alpha(IIb)beta3 complexes from the endoplasmic reticulum to the Golgi apparatus.Semantic proximity
Two homozygous missense mutations in ITGB3 gene as a cause of Glanzmann Thrombasthenia in four consanguineous Pakistani pedigrees.Semantic proximity
AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function.Semantic proximity
Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of<b>α</b>IIb<b>β</b>3 integrin (<i>ITGA2B, ITGB3</i>)Semantic proximity
Natural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: <i>in silico</i> docking models and energetics of the interaction with both LRP1 and GpIb A1 domainSemantic proximity
Select a neighboring publication to make it the new centre.